BDBM50183449 CHEMBL3823101::US11773085, Compound B23

SMILES COc1cc(c(OC)cc1CN(C)C)-c1cn(C)c(=O)c2cnccc12

InChI Key InChIKey=BJFSUDWKXGMUKA-UHFFFAOYSA-N

Data  16 IC50  13 Kd

PDB links: 5 PDB IDs match this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50183449   

TargetBromodomain-containing protein 7(Homo sapiens (Human))
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50183449(CHEMBL3823101 | US11773085, Compound B23)
Affinity DataIC50:  3.41E+3nMAssay Description:Inhibition of human BRD7 measured after mins by AlphaScreen assayMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 7(Homo sapiens (Human))
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50183449(CHEMBL3823101 | US11773085, Compound B23)
Affinity DataKd:  73nMAssay Description:Binding affinity to human BRD7 by BROMOScan analysisMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 7(Homo sapiens (Human))
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50183449(CHEMBL3823101 | US11773085, Compound B23)
Affinity DataKd:  239nMAssay Description:Binding affinity to human BRD7 expressed in Escherichia coli L21(DE3)-R3-pRARE2 cells by VP-ITC methodMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 7(Homo sapiens (Human))
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50183449(CHEMBL3823101 | US11773085, Compound B23)
Affinity DataKd:  418nMAssay Description:Binding affinity to recombinant human His-tagged BRD7 (129 to 250 residues) expressed in Escherichia coli BL21 DE3 assessed as dissociation constant ...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 7(Homo sapiens (Human))
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50183449(CHEMBL3823101 | US11773085, Compound B23)
Affinity DataKd:  79nMAssay Description:Binding affinity to BRD7 (unknown origin)More data for this Ligand-Target Pair
TargetBromodomain-containing protein 7(Homo sapiens (Human))
Boehringer Ingelheim Rcv

Curated by ChEMBL
LigandPNGBDBM50183449(CHEMBL3823101 | US11773085, Compound B23)
Affinity DataIC50:  3.41E+3nMAssay Description:Inhibition of human N-terminal GST-tagged BRD7 expressed in Escherichia coli using tetra-acetylated histone H4 measured after 60 mins by AlphaScreen ...More data for this Ligand-Target Pair